Sickle Cell and Marriage Compatibility: Take the best decision from now!

Sickle cell and marriage compatibility

One of the biggest problems to avoid for any couple is sickle cell types and marriage. Whereas most people will stick to the physical outlook (phenotype), a person’s genetic characteristics are more vital.

Genotype types (sickle cell)

Human genotypes are AA, AS, AC, and SS. These combinations refer to the constituents of hemoglobin gene found in red plasma cells. AC is a rare type, but AS and AC indicates an abnormality. Check out the genotype compatibility chart:

• AA + AA = AA, AA, AA, AA (Excellent)
• AA + AS = AA, AS, AA, AS, (Good)
• AA + SS = AS, AS, AS, AS, (Fair)
• AA + AC = AA, AA, AA, AC. (Good)
• AS + AS = AA, AS, AS, SS, (Very Bad)
• AS + SS = AS, SS, SS, SS, (Very Bad)
• AS + AC = AA, AC, AS,SS. (Bad; Advice needed)
• SS + SS = SS, SS, SS, SS, (Very Bad)
• AC + SS = AS, AS, SS, SS, (Very Bad)
• AC + AC = AA, AC, AC, SS. ( Bad; Advice needed)

Which blood group is the best?

Well, every blood group is perfect in its natural sense. But the ones that are considered better in transfusion include AB and O. While the former is a universal receiver, the latter is a universal donor. However, a person with an O+ blood group cannot transfuse to an O- person because of the Rh incompatibility. However, you can transfuse to a person with a B positive blood group or an A+ person.

So yes, sickle cell consideration in a person’s plasma group types matter in a marriage. The compatible genotypes that are marriage-compatible include:

• AA marrying AA. It is the best compatibility as you don’t have to worry about the genotype compatibility of your kids and posterity.
• AA marrying AS leads to kids with both AA and AS, which is still on the better side. However, it could lead to kids with AS, thus limiting the partners they can be with.
• AS and AS partners should not marry as they will most likely lead to children with SS combinations.
• AS and SS partners shouldn’t even consider marrying or having children.
• Finally, SS and SS is a no go zone. They have no chance of escaping a sickle cell disease.

The genotype characteristics of a person are fundamental. Before you say yes to that handsome guy or that beautiful lady who you intend to spend the rest of your life with, check your genotype. Blood group compatibility for marriage is a growing concern, but it can be controlled. Prior check before you decide to have a biological child is imperative and a precaution that can deter diverse outcomes.